Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Elective genomic sequencing for adults in research, clinical and commercial contexts.

BMC medical genomics·2026

Same author

Elective genomic sequencing for adults in research, clinical and commercial contexts.

medRxiv : the preprint server for health sciences·2026

Same author

The Barriers and Enablers to Implementing Child and Family Health Hubs for Migrant Families.

International journal of integrated care·2026

Same author

Hereditary Hemochromatosis and Hypertrophic Cardiomyopathy as Tier 1 Genomic Conditions: Implications for Adult Population Genomic Screening.

Public health genomics·2026

Same author

Imagining Genomics and Population Health in 2050: Anticipating Future Research, Policy, and Governance Needs.

Public health genomics·2026

Same author

Measuring the efficacy of a four-year longitudinal medical school disabilities curriculum.

BMC medical education·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

The genomic applications in practice and prevention network.

Muin J Khoury¹, W Gregory Feero, Michele Reyes

¹Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. mkhoury@cdc.gov

Genetics in Medicine : Official Journal of the American College of Medical Genetics

|May 28, 2009

Summary

The Genomic Applications in Practice and Prevention Network bridges the gap between genetic discoveries and clinical use. This initiative aims to integrate validated genomic knowledge into healthcare by addressing information and knowledge gaps.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Related Experiment Videos

Last Updated: Jun 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

Genomics
Translational Science
Public Health

Background:

A significant gap exists between genetic discoveries and their validated clinical utility.
Lack of accessible information and provider/consumer knowledge hinders genomic application implementation.
The Genomic Applications in Practice and Prevention Network was established to address these challenges.

Purpose of the Study:

To describe the rationale and initial development of the Genomic Applications in Practice and Prevention Network.
To outline the network's mission to accelerate genomic knowledge integration into medicine and public health.
To detail the network's multi-stakeholder approach involving academia, government, healthcare, industry, and consumers.

Main Methods:

The network convenes diverse stakeholders to foster collaboration.
It focuses on synthesizing knowledge, developing evidence-based recommendations, and conducting translation research.
Key domains include knowledge dissemination, evidence-based recommendations, real-world impact evaluation, and practice enhancement programs.

Main Results:

The network's development is based on addressing the chasm between gene discovery and clinical application.
It establishes a process linking genomic application information to knowledge synthesis, recommendation development, translation research, and practice enhancement.
The initiative aims to streamline the integration of validated genomic knowledge.

Conclusions:

The Genomic Applications in Practice and Prevention Network is a crucial initiative to bridge the gap in genomic medicine.
Effective integration requires addressing information access, knowledge deficits, and real-world validation.
The network's structured approach will facilitate the translation of genomic discoveries into clinical practice and public health strategies.