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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

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Related Experiment Video

Updated: Jun 22, 2026

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
14:21

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

High-speed optical frequency-domain imaging.

S Yun, G Tearney, Johannes de Boer

    Optics Express
    |May 28, 2009
    PubMed
    Summary
    This summary is machine-generated.

    We developed a high-speed, high-sensitivity optical imaging method using frequency-domain interferometry. This technique offers superior signal-to-noise ratio and resolution compared to existing optical coherence tomography methods.

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    Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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    High-speed Particle Image Velocimetry Near Surfaces

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    Area of Science:

    • Optical Imaging
    • Interferometry
    • Photonics

    Background:

    • Optical coherence tomography (OCT) is a key technology for high-resolution imaging.
    • Conventional OCT uses time-domain ranging, which can be limited in signal-to-noise ratio.
    • Advancements in laser technology enable new approaches to optical imaging.

    Purpose of the Study:

    • To demonstrate high-speed, high-sensitivity, and high-resolution optical imaging.
    • To compare frequency-domain ranging with time-domain ranging in optical imaging.
    • To leverage rapidly-tuned wavelength-swept lasers for enhanced performance.

    Main Methods:

    • Utilized optical frequency-domain interferometry (OFDI).
    • Employed a rapidly-tuned wavelength-swept laser source.
    • Derived and experimentally validated frequency-domain ranging principles.

    Main Results:

    • Achieved a signal-to-noise ratio superior to conventional time-domain ranging.
    • Obtained a sensitivity of -110 dB with a 6 mW source.
    • Reached an axial resolution of 13.5 micrometers at an A-line rate of 15.7 kHz.

    Conclusions:

    • Frequency-domain ranging offers significant advantages over time-domain ranging for optical imaging.
    • The developed OFDI method represents a substantial improvement over previous OCT and interferometric imaging techniques.
    • This technology enables unprecedented speed, sensitivity, and resolution in optical imaging.