Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anvisa authorization for electronic prescriptions of controlled substances: implications for equity in access to pain management in Brazil.

Cadernos de saude publica·2026
Same author

Evaluation of the effects of Plasma-Lyte 148 or 0.9% saline on acid-base balance in patients undergoing neurosurgery: a randomized clinical trial.

Einstein (Sao Paulo, Brazil)·2026
Same author

Developing a concise multivariable predictive model for cesarean delivery following neuraxial analgesia during labor: a prospective observational cohort study.

Brazilian journal of anesthesiology (Elsevier)·2026
Same author

Advancing pediatric anesthesia in Brazil: reflections on research and education.

Brazilian journal of anesthesiology (Elsevier)·2024
Same author

Beyond the bite: understanding and managing post-arboviral pain.

Brazilian journal of anesthesiology (Elsevier)·2024
Same author

Cannabinoid products for pain management: recommendations from the São Paulo State Society of Anesthesiology.

Brazilian journal of anesthesiology (Elsevier)·2024

Related Experiment Videos

[Accidental spinal metoclopramide injection: case report.].

Eduardo Barbosa Leão1, Guilherme Antônio Moreira de Barros, Yara Marcondes Machado Castiglia

  • 1Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, UNESP.

Revista Brasileira De Anestesiologia
|May 28, 2009
PubMed
Summary

Accidental intrathecal injection of metoclopramide during spinal anesthesia caused severe maternal symptoms. Prompt supportive care led to full recovery, highlighting the need for medication vigilance in anesthesia.

Related Experiment Videos

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Obstetrics

Context:

  • Accidental injection of non-spinal drugs into the epidural or spinal space is a known anesthetic complication.
  • This case involves a pregnant patient undergoing cesarean section requiring spinal anesthesia.

Purpose:

  • To report a case of inadvertent spinal injection of metoclopramide during spinal anesthesia.
  • To highlight the potential complications and management of such an event.

Summary:

  • A 17-year-old pregnant patient received spinal anesthesia for cesarean delivery.
  • Following injection, she experienced severe symptoms including hypertension, tachycardia, headache, nausea, and altered consciousness, attributed to inadvertent intrathecal metoclopramide.
  • Supportive care resulted in rapid symptom resolution and uneventful recovery.

Impact:

  • This case underscores the critical importance of meticulous drug identification and administration protocols in anesthesia.
  • Recommendations include standardizing vial colors and storage to prevent similar medication errors.
  • Emphasizes the need for vigilance to ensure patient safety during neuraxial anesthesia.