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Updated: Jun 22, 2026
07:18
Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
[Two-hour evaluation of renal function in the elderly].
Maria do Carmo B Sammartino Benarab1, Yara Marcondes Machado Castiglia, Pedro Thadeu Galvão Vianna
1FBM, UNESP, Brazil.
Revista Brasileira De Anestesiologia
|May 28, 2009
Summary
Elderly hypertensive patients showed altered sodium and potassium excretion. Estimated creatinine clearance correlated with actual clearance only in normotensive elderly, highlighting potential differences in renal function assessment.
Area of Science:
- Nephrology
- Geriatrics
- Cardiology
Context:
- Elderly individuals experience declining renal function.
- Hypertension exacerbates the risk of kidney injury in older adults.
- Accurate renal function assessment is crucial, especially in elderly hypertensive patients.
Purpose:
- To evaluate preoperative renal function in elderly hypertensive versus normotensive patients.
- To compare estimated creatinine clearance with actual creatinine clearance using a 2-hour urine collection.
- To assess the utility of portable ultrasound for measuring residual vesical volume (RVV) in this population.
Summary:
- This study compared renal function parameters in 30 elderly patients (15 hypertensive, 15 normotensive).
- Measurements included plasma/urinary electrolytes, osmolality, and creatinine clearance.
- Hypertensive patients exhibited higher sodium fractional excretion and lower plasma potassium, though within normal limits. Estimated creatinine clearance correlated with actual clearance only in normotensive individuals.
Impact:
- Findings suggest potential differences in renal handling of sodium and potassium in elderly hypertensive patients.
- The study highlights limitations in using estimated creatinine clearance for hypertensive elderly.
- Accurate RVV measurement using portable ultrasound may improve renal function evaluation in this demographic.
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