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Bioavailability Enhancement: Drug Solubility Enhancement

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Related Experiment Video

Updated: Jun 22, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution.

Young-Joon Park¹, Ram Kwon, Qi Zhe Quan

¹College of Pharmacy, Yeungnam University, Gyongsan, Korea.

Archives of Pharmacal Research

|May 28, 2009

Summary

This summary is machine-generated.

A novel ibuprofen solid dispersion formulation significantly enhances drug solubility and oral bioavailability in rats. This improved formulation offers a more effective delivery method for poorly water-soluble ibuprofen.

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Formation of Dispersible Taohong Siwu Tablets

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Last Updated: Jun 22, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID).
Poor aqueous solubility limits ibuprofen's oral bioavailability.
Developing advanced formulations is crucial for enhancing drug efficacy.

Purpose of the Study:

To develop and characterize a novel ibuprofen-loaded solid dispersion.
To investigate the impact of HPMC and poloxamer on ibuprofen solubility and dissolution.
To evaluate the enhanced bioavailability of the solid dispersion in vivo.

Main Methods:

Preparation of various ibuprofen-loaded solid dispersions using water, HPMC, and poloxamer.
Investigation of the effect of carrier composition (HPMC/poloxamer ratio) on ibuprofen's aqueous solubility.
In vivo pharmacokinetic studies in rats comparing solid dispersion to ibuprofen powder.

Main Results:

Increased carrier amount and altered HPMC/poloxamer ratio elevated ibuprofen's aqueous solubility.
A specific ibuprofen/HPMC/poloxamer (10:3:2 ratio) solid dispersion showed a 4-fold increase in drug solubility.
This solid dispersion demonstrated significantly higher plasma concentration, AUC, and Cmax in rats compared to ibuprofen powder.
Overall bioavailability was improved approximately 4-fold.

Conclusions:

The developed ibuprofen-loaded solid dispersion effectively enhances aqueous solubility and oral bioavailability.
This novel formulation represents a promising strategy for improving the therapeutic efficacy of poorly water-soluble ibuprofen.
The solid dispersion formulation is a more effective oral dosage form for ibuprofen delivery.