Related Experiment Video
Updated: Jun 22, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Effect of sildenafil on penile plethysmography responding: a pilot investigation
Nathan J Kolla1, Ray Blanchard, Philip E Klassen
1Law and Mental Health Program, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. nathan.kolla@utoronto.ca
Abstract:
Despite the utility of penile plethysmography in helping diagnose sexual offenders, some men respond minimally to the test stimuli. This pilot investigation examined the effect of sildenafil on phallometric responding in a non-forensic sample (n = 12) of middle-aged males. Participants underwent phallometric testing on two separate occasions and were administered 50 mg of sildenafil prior to one of these sessions. Study data indicated that pre-treatment with sildenafil produced a significant mean percentage increase (28%) in peak response compared with the untreated condition. The implication of this result is discussed in view of the selected sample.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Male Sexual Response: Erection & Ejaculation
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
