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The effect of scheduling in children undergoing prophylactic cranial irradiation for acute lymphoblastic leukaemia
S A Costello1, R D Jones, A Barrett
1Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, Glasgow, U.K.
Abstract:
Control of central nervous system (CNS) disease and overall survival have been analysed in a group of 829 children with leukaemia entered into the UKALL VIII trial to determine whether scheduling of the cranial irradiation is of prognostic significance. We show that short gaps in treatment do not influence prognosis and that current radiotherapy practice need not be modified.