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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Folding01:22

Protein Folding

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Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding01:22

Protein Folding

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Protein Organization01:13

Protein Organization

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Updated: Jun 22, 2026

Differential Scanning Calorimetry &#8212; A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
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Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen

Published on: March 4, 2017

Protein thermodynamic structure.

Qinyi Zhao1

  • 1Department of Biochemistry and Molecular Biology, Medical Institute, Beijing, People's Republic of China. qyzh@163bj.com

IUBMB Life
|May 28, 2009
PubMed
Summary

Protein science knowledge can be explained by thermodynamic structure theory. A new deductive system resolves fundamental protein science questions theoretically.

Area of Science:

  • Protein science
  • Biophysics
  • Structural biology

Background:

  • Protein research is typically experimental, lacking axiomatic foundations.
  • Current understanding relies heavily on empirical observations.

Purpose of the Study:

  • To demonstrate that protein thermodynamic structure theory can explain current protein science knowledge.
  • To develop a deductive system for protein knowledge.
  • To theoretically resolve fundamental questions in protein science.

Main Methods:

  • Application of protein thermodynamic structure theory principles.
  • Development of a deductive system for protein knowledge.

Main Results:

  • A significant portion of current protein science knowledge is explainable via thermodynamic principles.

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Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy

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Last Updated: Jun 22, 2026

Differential Scanning Calorimetry &#8212; A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
08:13

Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen

Published on: March 4, 2017

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy
10:09

Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy

Published on: April 28, 2011

  • The developed deductive system provides a theoretical framework for protein knowledge.
  • Fundamental questions in protein science were theoretically resolved.

    • Conclusions:

    • Protein thermodynamic structure theory offers a powerful framework for understanding protein science.
    • A deductive approach can advance theoretical resolution of key questions in the field.
    • This work bridges experimental observations with theoretical principles in protein research.