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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Updated: Jun 22, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Evolution of hyperacute stroke over 6 hours using serial MR perfusion and diffusion maps.

Ashley D Harris¹, Robert K Kosior, Henry S Chen

¹Seaman Family MR Research Centre, Foothills Medical Centre, University of Calgary, Alberta, Canada.

Journal of Magnetic Resonance Imaging : JMRI

|May 28, 2009

Summary

This study introduces a novel method to map infarct progression in ischemic stroke using apparent diffusion coefficient (ADC) changes. The technique reveals dynamic perfusion changes and supports the diffusion-perfusion mismatch hypothesis.

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2026-06-19T13:42:43.835274+00:00

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