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Updated: Jun 22, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease
B Jasinska-Myga1, C Wider, G Opala
1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. jasinskamyga.barbara@mayo.edu
Background And Purpose:
A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN.
Methods:
As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland.
Results:
No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis).
Conclusions:
This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.
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