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Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study
Charalabos Stratopoulos1, A Papakonstantinou, G Anagnostopoulos
1First Surgical Department and Transplant Unit, Evagelismos Hospital, Athens, Greece. harstrat@otenet.gr
European Journal of Cancer Care
|May 29, 2009
Summary
Neurofibromatosis type 1 (NF1) patients have a higher risk of tumors. This case highlights an extremely rare instance of NF1 with small-bowel adenocarcinoma, emphasizing its consideration in acute abdominal pain evaluations.
Area of Science:
- Oncology
- Gastroenterology
- Genetics
Background:
- Neurofibromatosis type 1 (NF1), or Von Recklinghausen's disease, predisposes patients to various neoplasms.
- Small-bowel adenocarcinoma is a rare malignancy, and its association with NF1 is exceptionally uncommon.
Observation:
- A 73-year-old male with NF1 presented with acute abdomen.
- Laparotomy revealed multiple ileal nodules causing obstruction and perforation.
- Histopathology confirmed NF1 with malignant transformation to small-bowel adenocarcinoma.
Findings:
- Surgical resection of the affected ileum and mesenteric nodules was performed.
- The patient experienced no recurrence after 2 years of follow-up without further therapy.
- This case represents a rare coexistence of NF1 and small-bowel adenocarcinoma.
Implications:
- Small-bowel adenocarcinoma should be considered in the differential diagnosis of acute abdominal pain in patients with NF1.
- Early recognition and management are crucial for improving outcomes in these rare cases.
- Further research may elucidate the specific mechanisms linking NF1 to small-bowel adenocarcinoma.
