Related Experiment Videos

Incidence and outcome of ischemic hepatitis complicating septic shock

Joan M Raurich1, Olatz Pérez, Juan A Llompart-Pou

  • 1Intensive Care Unit, Hospital Universitari Son Dureta, Palma de Mallorca, Illes Balears, Spain.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|May 29, 2009
PubMed

Insights

Ischemic hepatitis is a common complication in septic shock, affecting 13.8% of patients. This condition significantly increases the risk of death, highlighting its critical impact on septic shock outcomes.

Area of Science:

  • Critical Care Medicine
  • Hepatology
  • Infectious Diseases

Background:

  • The incidence of ischemic hepatitis in septic shock is not well-established.
  • Septic shock is a leading cause of intensive care unit (ICU) mortality.

Purpose of the Study:

  • To determine the incidence of ischemic hepatitis in patients with septic shock.
  • To investigate the association between ischemic hepatitis and mortality in septic shock.

Main Methods:

  • Retrospective study of 181 septic shock patients admitted to the ICU.
  • Ischemic hepatitis defined as serum aminotransferases ≥ 1000 IU/L.
  • Data collected included demographics, comorbidities, infection source, and Sequential Organ Failure Assessment (SOFA) scores.

Main Results:

  • Ischemic hepatitis occurred in 13.8% of patients (25/181).
  • In-hospital mortality was 57% overall, but 84% in patients with ischemic hepatitis versus 52.6% without.
  • Ischemic hepatitis, higher maximum SOFA scores, and inadequate antibiotic therapy were independent predictors of mortality.

Conclusions:

  • Ischemic hepatitis is a frequent complication in septic shock.
  • The presence of ischemic hepatitis is strongly associated with increased mortality in septic shock patients.
Abstract

Related Concept Videos

Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...