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Related Experiment Video

Updated: Jun 22, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Concurrent prophylactic left atrial appendage exclusion: results from a randomized controlled trial pilot study.

Atul Dave Nagpal1, Lucia Torracca, Andrea Fumero

  • 1Division of Cardiac Surgery, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada. adnagpal@uwo.ca

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|May 29, 2009
PubMed
Summary

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Left atrial appendage exclusion during mitral valve surgery is safe and feasible. This pilot study found no increased complications or adverse events in patients undergoing concomitant appendage exclusion.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Thrombosis Research

Background:

  • The left atrial appendage is a primary source of cardioembolic thrombi.
  • Open mitral valve surgery offers a window for left atrial appendage exclusion.
  • Limited randomized data exists for this combined procedure.

Purpose of the Study:

  • To assess the safety and feasibility of concomitant left atrial appendage exclusion during open mitral valve surgery.
  • To evaluate early clinical and biochemical outcomes of this surgical approach.
  • To inform the design of a larger, powered randomized controlled trial.

Main Methods:

  • A pilot randomized controlled trial involving 43 patients.
  • Patients were randomized to either suture exclusion of the left atrial appendage or a control group during open mitral valve surgery.

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Last Updated: Jun 22, 2026

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Published on: February 26, 2013

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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  • Postoperative outcomes, including clinical, biochemical, hemodynamic, and hemostatic parameters, were analyzed.

    • Main Results:

    • No deaths occurred in either group.
    • Major postoperative complication rates were similar: 32% in the exclusion group vs. 38% in the control group (p=0.75).
    • Intensive care and hospital lengths of stay were comparable, with no significant differences in hemodynamic or hemostatic complications.

    Conclusions:

    • This pilot trial confirms the safety and feasibility of concomitant left atrial appendage exclusion during mitral valve surgery.
    • The findings support the rationale for a larger randomized trial to determine definitive short- and long-term outcomes.
    • Left atrial appendage exclusion can be safely integrated into mitral valve surgery procedures.