Related Experiment Video
Updated: Jun 22, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Hepatocellular carcinoma complicating cystic fibrosis related liver disease
D H O'Donnell1, R Ryan, B Hayes
1Department of Radiology, St Vincent's University Hospital, Dublin 4, Ireland. davidhodonnell@hotmail.com
Abstract:
Early diagnosis and treatment of the respiratory and gastrointestinal complications of cystic fibrosis (CF) have led to improved survival with many patients living beyond the fourth decade. Along with this increased life expectancy is the risk of further disease associated with the chronic manifestations of their condition. We report a patient with documented CF related liver disease for which he was under routine surveillance that presented with histologically proven hepatocellular carcinoma (HCC). It is important that physicians are aware of this association as increased vigilance may lead to earlier diagnosis and perhaps, a better outcome.
Related Concept Videos
Cirrhosis II: Pathophysiology
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cirrhosis I: Introduction
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Hepatitis
Chronic Pancreatitis II: Pathophysiology
