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Related Experiment Video

Updated: Jun 22, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Ipilimumab-induced hypophysitis: MR imaging findings.

K J Carpenter1, R D Murtagh, H Lilienfeld

  • 1Department of Radiology, University of South Florida, Tampa, FL 33629, USA.

AJNR. American Journal of Neuroradiology
|May 29, 2009
PubMed
Summary

Ipilimumab, an immunotherapy drug, can cause hypophysitis, an autoimmune side effect. Prompt diagnosis and treatment with steroids led to rapid improvement in three patients with metastatic melanoma and renal cell carcinoma.

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Area of Science:

  • Immunotherapy
  • Oncology
  • Endocrinology

Background:

  • Ipilimumab is an antineoplastic agent used for metastatic melanoma and renal cell carcinoma.
  • Advances in immunotherapy have introduced novel side effects.
  • Hypophysitis is a potential adverse event associated with ipilimumab treatment.

Observation:

  • Three patients developed hypophysitis during ipilimumab therapy.
  • The condition was suspected to be autoimmune due to ipilimumab's mechanism and other autoimmune phenomena.
  • Patients showed significant and rapid improvement after drug discontinuation and steroid administration.

Findings:

  • This study presents the imaging findings in three patients with presumed ipilimumab-induced hypophysitis.
  • Imaging characteristics aid in diagnosing this specific side effect.

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Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Related Experiment Videos

Last Updated: Jun 22, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

  • Early identification of hypophysitis is crucial for effective management.

    • Implications:

    • Recognizing ipilimumab-induced hypophysitis is essential for oncologists and endocrinologists.
    • Prompt diagnosis and treatment can mitigate severe outcomes.
    • Understanding these side effects improves patient care in cancer immunotherapy.