Related Experiment Video
Updated: Jun 22, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
Gorham's massive osteolysis of the mandible - a progressive radiographic presentation
1Department of Oral and Maxillofacial Surgery, Dayananda Sagar College of Dental Sciences, Bangalore 560 003, Karnataka, India. prof.hpr@rediffmail.com
Abstract:
Massive osteolysis is well known under the synonyms Gorham's disease, vanishing bone disease and phantom bone disease. It is a rare condition of unknown aetiology and results in the progressive destruction of bony structures. Only a few cases have been reported in the jaws. Considering the rarity of the condition, we report here an interesting and unique case of massive osteolysis of the lower jaw that initially affected the mandibular basal and alveolar bone, and subsequently involved the rami and the condyles. The clinical and radiological findings were consistent with the criteria for the diagnosis of Gorham's massive osteolysis.
Related Concept Videos
Gross Anatomy of Bone
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
Bone Remodeling
Osteoclasts in Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

