Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Summary of Research: Four-Year Outcomes of Faricimab in Diabetic Macular Edema: Results From the RHONE-X Extension Trial.

Ophthalmology and therapy·2026
Same author

Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial.

JAMA network open·2026
Same author

Feasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.

Eye (London, England)·2026
Same author

Visual Field Estimation in X-Linked Retinitis Pigmentosa Associated with Retinitis Pigmentosa GTPase Regulator (<i>RPGR</i>) from Image Analysis Using Artificial Intelligence.

Ophthalmology science·2026
Same author

Can provision of near vision glasses as an early intervention improve visual outcomes in infants at risk of perinatal brain insult? The Babies in Glasses (BiG) randomised feasibility trial.

BMJ open·2026
Same author

Advancing glaucoma care: What's new in the 6th edition of the European Glaucoma Society guidelines.

European journal of ophthalmology·2026
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Optic disc and visual field changes after trabeculectomy.

Aachal Kotecha1, Alexander Spratt, Catey Bunce

  • 1National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. aachalkotecha@gmail.com

Investigative Ophthalmology & Visual Science
|May 29, 2009
PubMed
Summary
This summary is machine-generated.

Glaucoma progression was observed in approximately one third of eyes five years after trabeculectomy, impacting optic nerve head structure and visual field sensitivity. Lower intraocular pressure reduction post-surgery correlated with increased glaucoma progression.

Related Experiment Videos

Last Updated: Jun 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Glaucoma research
  • Surgical outcomes

Background:

  • Trabeculectomy is a common surgical procedure to manage glaucoma.
  • Monitoring glaucoma progression involves assessing optic nerve head (ONH) structure and visual field (VF) sensitivity.
  • Long-term outcomes of trabeculectomy require continued investigation.

Purpose of the Study:

  • To evaluate changes in ONH structure and VF sensitivity over time in glaucoma patients following trabeculectomy.
  • To identify factors associated with glaucoma progression post-surgery.

Main Methods:

  • Prospective randomized controlled trial (MoreFlow Medical Research Council 5-Fluorouracil study) analyzing 80-month data.
  • Annual ONH imaging and 4-month VF testing for patients with at least 3 years of postoperative data.
  • Linear regression analysis for ONH rim area changes and point-wise linear regression analysis for VF sensitivity; intraocular pressure (IOP) levels and fluctuations were also assessed.

Main Results:

  • Twenty-eight percent (70 of 250 eyes) showed glaucoma progression at approximately 5 years post-surgery, detected by ONH, VF, or both.
  • Eyes with progression exhibited slightly higher median follow-up IOP and lower IOP reduction percentages compared to non-progressors.
  • Only 3% of the total cohort showed concurrent ONH and VF changes in the same location.

Conclusions:

  • Approximately one-third of eyes demonstrate continued glaucoma progression five years after trabeculectomy, based on structural and functional assessments.
  • The degree of intraocular pressure reduction achieved after trabeculectomy appears crucial in influencing glaucoma progression, as detected by both structural and functional measures.