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Direct interaction between human endometrial carcinoma and fibroblast: fibroblast-derived growth factor
1Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Research Communications in Chemical Pathology and Pharmacology
|September 1, 1991
Abstract:
Epithelial-stromal interaction was investigated in human endometrial carcinoma. The medium cultured with fibroblasts derived from human endometrial carcinoma tissue increased [3H]thymidine incorporation into and estrogen receptor level of endometrial carcinoma (Hashimoto) cells. Concomitant exposure to estradiol, but not to progesterone, synergistically enhanced the conditioned medium-induced events. These findings demonstrated direct interaction of epithelial cells and its stromal cells in endometrial carcinoma.