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Fibroblast activation and myofibroblast generation in obstructive nephropathy

María T Grande1, José M López-Novoa

  • 1Instituto Reina Sofía de investigación Nefrológica, Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain.

Nature Reviews. Nephrology
|May 29, 2009
PubMed
Summary

Obstructive nephropathy causes kidney failure by activating fibroblasts and promoting epithelial-mesenchymal transition, leading to interstitial fibrosis. Targeting these processes may prevent or reverse renal dysfunction.

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