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Published on: August 28, 2021
[Dexmedetomidine: pharmacology and clinical application.]
Airton Bagatini1, Cláudio Roberto Gomes, Marcelo Zanettini Masella
1CET, SBA, SANE.
Background And Objectives:
Dexmedetomidine is the newest alpha2-adrenergic agonist for clinical application. It has a fast onset, is metabolized by the liver and mostly excreted by the urine. This review aimed at presenting pharmacokinetic and pharmacodynamic profiles of dexmedetomidine and its clinical applications.
Contents:
Dexmedetomidine pharmacokinetic and pharmacodynamic profiles are presented and compared to other alpha2-adrenergic agonist drugs, the prototype of which is clonidine. Cardiac, vascular, neurological and gynecologic procedure outcomes are commented.
Conclusions:
Dexmedetomidine is an innovative drug for sedation and analgesia. Its major qualities are fast onset and titration, allowing for changes in sedation and analgesia depth. In addition, it has a synergism with commonly used anesthetic drugs, with a low incidence of side effects and minor respiratory depression.
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