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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Related Experiment Video

Updated: Jun 22, 2026

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Published on: December 14, 2009

Live cell optical sensing for high throughput applications.

¹Biochemical Department, Science and Technology Division, Corning Incorporated, Corning, New York, 14831, USA, fangy2@corning.com.

Advances in Biochemical Engineering/Biotechnology

|May 29, 2009

Summary

This summary is machine-generated.

Live cell optical sensing uses label-free biosensors to measure cell responses to stimuli. This technique is valuable for studying cell biology and drug discovery, especially with high-throughput assays.

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Last Updated: Jun 22, 2026

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Area of Science:

Biotechnology
Cell Biology
Pharmacology

Background:

Live cell optical sensing offers non-invasive methods for studying cellular dynamics.
Dynamic mass redistribution (DMR) is an integrated cellular response to external stimuli.
Label-free biosensors are crucial for real-time monitoring of cellular activities.

Purpose of the Study:

To describe the applications of live cell optical sensing in cell biology research.
To highlight the utility of this technique in ligand pharmacology.
To emphasize the role of resonant waveguide grating biosensors in high-throughput cellular assays.

Main Methods:

Utilizing label-free optical biosensors to detect dynamic mass redistribution (DMR).
Measuring stimulus-induced cellular responses in real-time.
Employing resonant waveguide grating biosensor technology for cellular assays.

Main Results:

DMR signals provide insights into cell signaling pathways.
The technique allows for non-invasive assessment of cellular responses.
High-throughput applications are feasible using resonant waveguide grating biosensors.

Conclusions:

Live cell optical sensing is a powerful tool for understanding cell biology.
This method facilitates the study of drug-target interactions in pharmacology.
Resonant waveguide grating biosensors enable efficient, high-throughput analysis of cellular responses.