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Heat shock proteins in children and young adults on chronic hemodialysis

Kinga Musiał1, Krystyna Szprynger, Maria Szczepańska

  • 1Department of Pediatric Nephrology, Wrocław Medical University, 50-369 Wrocław, Poland.

Pediatric Nephrology (Berlin, Germany)
|May 29, 2009
PubMed

Insights

Heat shock proteins (HSP) and their antibodies are altered in children undergoing hemodialysis (HD), correlating with lipid profiles and potentially serving as new atherosclerosis markers.

Area of Science:

  • Biochemistry
  • Immunology
  • Pediatric Nephrology

Background:

  • Atherosclerosis is linked to chronic inflammation and lipid disorders.
  • Hemodialysis (HD) may accelerate atherosclerosis.
  • Heat shock proteins (HSP) and anti-HSP antibodies are implicated in adult atherosclerosis, but data in pediatric HD patients are scarce.

Purpose of the Study:

  • To investigate the HSP profile in children undergoing HD.
  • To assess the impact of a single HD session on HSPs and related markers.
  • To correlate HSP levels with atherosclerosis risk factors in pediatric HD patients.

Main Methods:

  • Studied 17 children and young adults on HD and 15 controls.
  • Measured serum concentrations of Hsp60, Hsp90alpha, anti-Hsp60, anti-Hsp70, sE-selectin, and high-sensitivity C-reactive protein.
  • Assessed lipid profiles (total cholesterol, HDL-C, LDL-C, triglycerides).

Main Results:

  • Before HD, children had lower Hsp60 but higher Hsp90alpha and anti-Hsp60 compared to controls.
  • A single HD session increased Hsp60 and Hsp90alpha, while decreasing anti-Hsp60 and anti-Hsp70.
  • HSP and anti-HSP levels correlated with lipid markers both before and after HD.

Conclusions:

  • Children on HD exhibit altered HSP and anti-HSP concentrations.
  • These alterations correlate with lipid profiles and endothelial markers.
  • The HSP system may be dysfunctional in pediatric HD patients, suggesting HSPs as potential novel atherosclerosis markers.

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