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The association between MIF-173 G>C polymorphism and prostate cancer in southern Chinese
1Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background And Objectives:
Accumulating epidemiological and molecular evidence suggests that inflammation is an important component in the etiology of PCa. Macrophage migration inhibitory factor (MIF) plays an important role in the pro- and anti-inflammatory response to infection. This study is aimed at investigating the potential association between MIF-173 G>C polymorphism, Gleason score, clinical stage, and prostate-specific antigen (PSA) value with respect to PCa incidence among the Han nationality in Southern China.
Methods:
Genotyping was performed by using tetraprimer polymerase chain reaction (PCR) on 259 PCa patients and 301 cancer-free controls.
Results:
We found that the MIF-173*C variant allele was significantly associated with an increased risk of PCa [adjusted odd ratio (OR) = 2.99, 95% confident interval (CI): 1.94-4.60] and higher Gleason scores from the PCa subjects (adjusted OR = 10.72, 95% CI: 5.35-21.49). In addition, we noted that the MIF -173*C variant allele was related to higher clinical stages and PSA values in PCa patients (adjusted OR = 15.68, 95% CI: 7.40-33.23; adjusted OR = 4.37, 95% CI: 2.41-7.92, respectively).
Conclusion:
Our data suggest that MIF-173 polymorphisms may be associated with a higher incidence of prostate cancer compared to controls, and appears to be associated with higher Gleason scores, higher clinical stages, and PSA values in those with prostate cancer.
Insights
The MIF-173*C variant allele is linked to a higher risk of prostate cancer (PCa) and more aggressive disease indicators. This genetic factor may influence PCa incidence and progression in Southern Chinese Han populations.
Area of Science:
- Genetics and Molecular Biology
- Oncology
- Immunology
Background:
- Inflammation is implicated in prostate cancer (PCa) development.
- Macrophage migration inhibitory factor (MIF) is a key regulator of inflammatory responses.
- The role of MIF genetic variations in PCa risk and progression requires further investigation.
Purpose of the Study:
- To investigate the association between the MIF-173 G>C polymorphism and PCa incidence.
- To explore the relationship between this polymorphism and PCa clinical parameters like Gleason score, clinical stage, and prostate-specific antigen (PSA) levels.
Main Methods:
- Genotyping of the MIF-173 G>C polymorphism using tetraprimer polymerase chain reaction (PCR).
- Case-control study design involving 259 PCa patients and 301 cancer-free controls from the Han nationality in Southern China.
Main Results:
- The MIF-173*C variant allele was significantly associated with an increased risk of PCa (OR = 2.99).
- Carriage of the MIF-173*C allele correlated with higher Gleason scores (OR = 10.72), advanced clinical stages (OR = 15.68), and elevated PSA values (OR = 4.37).
Conclusions:
- MIF-173 polymorphisms may be associated with a higher incidence of prostate cancer.
- The MIF-173*C variant appears to be a risk factor for more aggressive PCa, indicated by higher Gleason scores, clinical stages, and PSA values.
