Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Service providers' perceptions of the strengths and prospective improvements in UK eating disorder services: findings from a Royal College survey.

European eating disorders review : the journal of the Eating Disorders Association·2011
Same author

Pelvic ultrasonography in anorexia nervosa: what the clinician should ask the radiologist and how to use the information provided.

European eating disorders review : the journal of the Eating Disorders Association·2007
Same author

Restoration of ovarian and uterine maturity in adolescents with anorexia nervosa.

The International journal of eating disorders·2002
Same author

Body image treatment within an inpatient program for anorexia nervosa: the role of mirror exposure in the desensitization process.

The International journal of eating disorders·2002

Related Experiment Video

Updated: Jun 22, 2026

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Autophonia in anorexia nervosa.

Meghana Godbole1, Adrienne Key

  • 1South West London and St George's Mental Health NHS Trust, London, United Kingdom. pollyann77@yahoo.com

The International Journal of Eating Disorders
|May 29, 2009
PubMed
Summary

Clinicians should be aware that otolaryngologic symptoms in very low weight anorexia nervosa patients may stem from fatty tissue loss around the Eustachian tube. Weight gain leads to notable symptom improvement.

Area of Science:

  • Otolaryngology
  • Eating Disorders
  • Clinical Medicine

Background:

  • Anorexia nervosa, particularly severe cases, presents complex medical challenges.
  • Otolaryngologic symptoms are frequently observed in patients with eating disorders.
  • The underlying causes of these symptoms in underweight patients require further investigation.

Observation:

  • Patients with very low weight anorexia nervosa exhibited specific otolaryngologic symptoms.
  • Clinical examinations revealed normal tympanic membranes despite reported symptoms.
  • Symptoms showed significant improvement with weight restoration during inpatient treatment.

Findings:

  • The study suggests that loss of peritubal fatty tissue may be a primary cause of otolaryngologic symptoms in this population.

More Related Videos

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Hyponeophagia: A Measure of Anxiety in the Mouse
05:52

Hyponeophagia: A Measure of Anxiety in the Mouse

Published on: May 17, 2011

Related Experiment Videos

Last Updated: Jun 22, 2026

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Hyponeophagia: A Measure of Anxiety in the Mouse
05:52

Hyponeophagia: A Measure of Anxiety in the Mouse

Published on: May 17, 2011

  • Weight gain correlates with the resolution of these symptoms, supporting the fatty tissue hypothesis.
  • Standard otolaryngologic examinations may not reveal the cause of symptoms in severely underweight patients.

    • Implications:

    • Increased clinician awareness is crucial for accurate diagnosis and management of otolaryngologic symptoms in anorexia nervosa.
    • This understanding can guide targeted interventions and improve patient care.
    • Further research into the anatomical and physiological changes associated with severe underweight is warranted.