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Changes in the QT interval during obstructive sleep apnea.

A M Gillis1, R Stoohs, C Guilleminault

  • 1Sleep Disorders Research Center, Stanford University School of Medicine, Palo Alto, California 94304.

Sleep
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Obstructive sleep apnea (OSA) significantly prolongs the QT interval, a measure of heart repolarization, increasing arrhythmia risk. Effective OSA treatment normalized these QT interval variations.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Electrophysiology

Background:

  • Ventricular repolarization abnormalities are linked to life-threatening arrhythmias.
  • Obstructive Sleep Apnea Syndrome (OSAS) may impact cardiac electrophysiology.

Purpose of the Study:

  • To evaluate the effects of obstructive sleep apnea on QT interval and cardiac repolarization.
  • To assess QT and RR interval changes during different phases of sleep apnea.

Main Methods:

  • Analyzed 70 OSAS episodes in 12 male patients during non-rapid eye movement (NREM) sleep.
  • Measured RR, QT, and corrected QT (QTc) intervals before, during, and after apnea events.
  • Compared intervals during quiet sleep, apnea onset, OSAS, and postapnea hyperventilation.

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Main Results:

  • RR interval significantly prolonged during OSAS and shortened post-apnea.
  • QT interval prolonged at apnea onset and further during OSAS.
  • QTc interval showed significant prolongation at apnea onset and shortening during apnea and post-apnea periods.
  • Effective OSAS therapy normalized RR, QT, and QTc interval variations during NREM sleep.

Conclusions:

  • Obstructive sleep apnea causes significant alterations in ventricular repolarization (QT interval).
  • These repolarization changes are reversed with effective OSAS treatment.
  • OSAS is associated with electrophysiological changes that may increase arrhythmia risk.