Related Experiment Video

Updated: Jun 22, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Cleft lip and palate: association with other congenital malformations

Soraya Beriaghi1, Sandra L Myers, Scott A Jensen

  • 1Cleft Palate and Craniofacial Clinic, Division of Pediatric Dentistry School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA. beira001@umn.edu

The Journal of Clinical Pediatric Dentistry
|May 30, 2009
PubMed

Insights

Orofacial clefts often accompany other congenital anomalies. This study found 32.2% of patients had associated malformations, most frequently in the orofacial region, highlighting the need for comprehensive evaluation.

Area of Science:

  • Medical Genetics
  • Pediatric Surgery
  • Developmental Biology

Background:

  • Orofacial clefts are common congenital conditions.
  • These conditions are frequently linked with other birth defects.
  • Understanding the spectrum of associated anomalies is crucial for patient care.

Purpose of the Study:

  • To investigate the prevalence and types of congenital malformations associated with orofacial clefts.
  • To analyze differences in associated anomalies between cleft palate only (CP) and cleft lip with or without cleft palate (CL +/- P) patient groups.

Main Methods:

  • Retrospective review of 1127 patients' medical records from a major research hospital's Cleft Palate/Craniofacial Clinic (1980-2000).
  • Patients were classified into CP or CL +/- P groups.
  • Associated malformations were categorized by location, type, and whether they were chromosomal/syndromic or non-chromosomal/syndromic.

Main Results:

  • 32.2% of all patients with orofacial clefts exhibited associated congenital malformations.
  • The orofacial region was the most common site for anomalies, followed by cardiovascular, central nervous, and skeletal systems.
  • Congenital malformations were more prevalent in patients with cleft palate only (38.7%) compared to cleft lip +/- palate (26.4%). 63.1% of diagnosed malformations were chromosomal/syndromic.

Conclusions:

  • A significant proportion of orofacial cleft patients present with associated congenital malformations.
  • The orofacial region is the most commonly affected site.
  • Identifying these associated anomalies is vital for guiding further diagnostic tests and genetic counseling.
Abstract

More Related Videos

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Quantification of Orofacial Phenotypes in Xenopus09:26

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...