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Published on: May 7, 2019
Immune thrombocytopenic purpura among the children attending at two teaching hospitals
Md Golam Hafiz1, M A Mannan, Syed Khairul Amin
1Department of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Insights
Immune thrombocytopenic purpura (ITP) in children shows a summer peak incidence. Management varies, with observation for some and treatments like corticosteroids for others, highlighting seasonal trends in pediatric ITP.
Area of Science:
- Pediatric Hematology
- Immunology
- Clinical Research
Background:
- Immune thrombocytopenic purpura (ITP) is an autoimmune disorder affecting platelet counts.
- Understanding ITP's clinical features and management in children is crucial for effective care.
- Seasonal variations in ITP incidence may influence diagnostic and treatment strategies.
Purpose of the Study:
- To evaluate the presenting features, diagnosis, seasonal variation, and management of immune thrombocytopenic purpura (ITP) in children.
- To identify any seasonal predilection for ITP in pediatric populations.
- To analyze the different management approaches employed for pediatric ITP.
Main Methods:
- Retrospective evaluation of 110 children diagnosed with ITP at two tertiary hospitals.
- Analysis of presenting features, diagnostic workup, and treatment protocols.
- Assessment of seasonal incidence patterns and patient outcomes.
Main Results:
- A peak incidence of pediatric ITP was observed during summer months (June, July), with the lowest incidence in autumn/winter (October-December).
- The mean initial platelet count was 65.5 x 10(9)/L.
- 35 children were managed with observation, while 75 received treatments including intravenous immunoglobulin and corticosteroids; two cases of intracranial hemorrhage were reported.
Conclusions:
- ITP in children exhibits a seasonal predilection, with a higher incidence during summer.
- Management approaches for pediatric ITP are variable, ranging from observation to active pharmacological treatment.
- Further research into seasonal influences on ITP pathogenesis and outcomes is warranted.
Abstract:
The presenting features, diagnostic evaluation, seasonal variation and management performed in 110 children with immune thrombocytopenic purpura (ITP) attending at two tertiary level hospitals were evaluated. A peak incidence of children with ITP was observed during the month of June, July and the first step was found in May and lowest in the month of October to December. Mean initial platelet count was 65.5 x 10(9)/L. 35 patients with ITP did not require any treatment who were kept under observation and the rest 75 children who were admitted to hospital given platelet count enhancing treatment- intravenous immunoglobulin in 9, corticosteroids in 60 or both in 6 children with ITP. Intracranial hemorrhages were noticed in two children with ITP. So, this study suggests that ITP had special predilection during summer season and the least in winter along with variable approaches to management of these children.
