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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions
Andrea Hall1, P A Karplus, Leslie B Poole
1Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA.
Abstract:
Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.
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