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Related Experiment Video

Updated: Jun 22, 2026

Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Published on: June 14, 2024

Transpleural perfusion with oxygenated perfluorocarbon increases systemic oxygenation.

Sungsoo Lee¹, Sukki Cho, Kay-Hyun Park

¹Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Gyeonggi-do 463-707, South Korea.

Respirology (Carlton, Vic.)

|May 30, 2009

Summary

Perfusion of the thoracic cavity with oxygenated perfluorocarbon significantly increased systemic oxygenation in a rat model of hypoxia. This novel method shows promise for treating reversible pulmonary failure without causing lung damage.

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Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Area of Science:

Physiology
Medical Devices
Biomaterials

Background:

Hypoxia due to pulmonary failure requires new methods for systemic oxygenation.
Current treatments may be insufficient for certain patients.

Purpose of the Study:

To investigate the efficacy of perfusing the thoracic cavity with oxygenated perfluorocarbon for enhancing systemic oxygenation in an animal model of induced hypoxia.

Main Methods:

Hypoxia was induced in Sprague-Dawley rats via hypoventilation.
The thoracic cavity was cannulated and perfused with either oxygenated saline or oxygenated perfluorocarbon.
Arterial blood gases were monitored, and histological examination was performed.

Main Results:

Animals receiving perfluorocarbon perfusion showed significantly higher PaO2 and lower PaCO2 compared to control groups.
Histological analysis revealed no adverse effects on lung or pleural tissue.

Conclusions:

Thoracic cavity perfusion with oxygenated perfluorocarbon effectively increases systemic oxygenation in a hypoxia model.
This technique may offer a viable therapeutic option for managing reversible pulmonary failure without inducing lung damage.