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Updated: Jun 22, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Aortic angiosarcoma with cutaneous metastases.

Ioannis Tsolakis¹, George Lampropoulos, Vassiliki Zolota

¹Department of Vascular Surgery, University Hospital of Patras, Rion, Greece.

|May 30, 2009

Summary

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Primary aortic angiosarcoma, a rare cancer, can mimic atherosclerosis. Early detection and multidisciplinary management are crucial for improving survival in patients with this aggressive vascular tumor.

Area of Science:

Vascular oncology
Surgical pathology
Aortic diseases

Background:

Primary aortic tumors, including angiosarcomas, are exceptionally rare, with limited documented cases.
Diagnosis is typically confirmed via histopathology post-surgery or autopsy.

Observation:

A case of primary aortic angiosarcoma presented with symptoms mimicking aortoiliac atherosclerotic disease, including intermittent claudication.
Initial treatment involved stenting, but metastatic skin lesions in the lower extremities emerged during follow-up.

Findings:

Resection of the aortic bifurcation and bypass grafting were performed due to metastatic disease.
Despite tumor recurrence post-surgery, aggressive multidisciplinary care resulted in a 3-year survival.

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Last Updated: Jun 22, 2026

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Published on: May 3, 2021

Implications:

This case highlights the importance of considering rare vascular tumors in differential diagnoses, even with typical atherosclerotic findings.
Aggressive, multidisciplinary management strategies can potentially prolong survival in patients with primary aortic angiosarcoma.
Further research into early diagnostic markers and targeted therapies for aortic angiosarcomas is warranted.