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Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors
X Christopher Sheng1, Hyung-Jung Pyun, Kleem Chaudhary
1Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA. csheng@gilead.com
Abstract:
A novel class of phosphonate derivatives was designed to mimic the interaction of product-like carboxylate based inhibitors of HCV NS3 protease. A phosphonic acid (compound 2) was demonstrated to be a potent HCV NS3 protease inhibitor, and a potential candidate for treating HCV infection. The syntheses and preliminary biological evaluation of this phosphonate class of inhibitor are described.
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