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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Minireview: live and let die: molecular effects of glucocorticoids on bone cells

Lorenz C Hofbauer1, Martina Rauner

  • 1Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University of Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. lorenz.hofbauer@uniklinikum-dresden.de

Molecular Endocrinology (Baltimore, Md.)
|May 30, 2009
PubMed

Insights

Glucocorticoids (GCs) treat immune diseases but cause osteoporosis. New GC receptor agonists offer targeted gene regulation, potentially reducing bone loss and improving therapies for bone conditions.

Area of Science:

  • Bone Biology
  • Endocrinology
  • Pharmacology

Background:

  • Glucocorticoids (GCs) are vital for treating immune-mediated diseases.
  • Long-term GC use leads to metabolic side effects, notably osteoporosis.
  • The glucocorticoid receptor (GC) mediates GC actions.

Purpose of the Study:

  • To review the cellular and molecular effects of GCs on bone cells.
  • To highlight signaling pathways for future therapeutic strategies.
  • To explore selective GC receptor modulators.

Main Methods:

  • Literature review of cellular and molecular mechanisms.
  • Analysis of glucocorticoid receptor signaling pathways.
  • Examination of GC effects on bone metabolism.

Main Results:

  • GCs exert complex effects on bone cells, influencing both formation and resorption.
  • GC receptor (GC) signaling pathways are key targets for modulating GC activity.
  • Selective GC receptor agonists show potential for dissociating therapeutic and adverse effects.

Conclusions:

  • Understanding GC actions on bone is crucial for mitigating side effects.
  • Targeting specific GC receptor pathways may lead to novel osteoporosis treatments.
  • Future strategies involve developing selective modulators to minimize bone loss.

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