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Updated: Jun 22, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
2D dosimetry in a proton beam with a scintillating GEM detector
E Seravalli1, M R de Boer, F Geurink
1Delft University of Technology, Faculty of Applied Sciences, Delft, The Netherlands. e.seravalli@tudelft.nl
A new scintillating gas detector with Gas Electron Multipliers (GEM) offers stable and reproducible 2D dose measurements for particle therapy verification. Its linear response and fast signal are ideal for precise radiation dosimetry.
Area of Science:
- Medical Physics
- Radiation Detection
- Particle Therapy
Background:
- Particle therapy requires precise pre-treatment verification of dose distributions.
- Scintillating gas detectors offer a potential solution for 2D dosimetry.
- Gas Electron Multipliers (GEM) enhance gas multiplication for photon emission detection.
Purpose of the Study:
- To characterize a novel 2D position-sensitive dosimetry system using a scintillating gas detector with GEM structures.
- To evaluate the detector's performance for relative dose measurements in particle therapy.
- To assess key properties including response reproducibility, dose and dose rate dependence, and spatial/temporal response.
Main Methods:
- Development of a dosimetry system using an Ar/CF(4) scintillating gas mixture and dual GEM structures.
- Detection of emitted photons using a mirror-lens-CCD camera system.
- Characterization experiments conducted using a 150 MeV proton beam, evaluating response stability, linearity, dose rate, field size, and temporal/spatial resolution.
Main Results:
- The detector demonstrated high stability with successive measurements (sigma = 0.6%) and good reproducibility over 2 days (approx. 5%).
- A linear dose response was observed in the range of 0.05-19 Gy.
- No significant dose rate effects were found within tested ranges, and no field size effects were observed for areas between 120-3850 mm(2). A spatial response of <= 1 mm and a signal rise/fall time of 2 microseconds were measured.
Conclusions:
- The scintillating GEM detector is a promising tool for 2D dose distribution verification in particle therapy.
- Its characterized properties, including stability, linearity, and spatial resolution, meet the requirements for precise dosimetry.
- The system's performance indicates its suitability for real-time or near-real-time pre-treatment dose verification.
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