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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jun 22, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Ischemic colitis: surging waves of update.

Michael Stamatakos1, Emmanuel Douzinas, Charikleia Stefanaki

  • 1Fourth Department of Surgery, Medical School, University of Athens, ATTIKON General Hospital, Athens, Greece. stamatakosmih@yahoo.gr

The Tohoku Journal of Experimental Medicine
|May 30, 2009
PubMed
Summary
This summary is machine-generated.

Ischemic colitis, a common intestinal ischemia, results from blocked blood flow to the large intestine. Early diagnosis and conservative treatment improve outcomes, but severe cases may require surgery.

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
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Published on: January 19, 2010

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

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Published on: January 5, 2017

Area of Science:

  • Gastroenterology
  • Vascular Surgery

Background:

  • Ischemic colitis is the most frequent form of intestinal ischemia, often affecting the elderly due to arterial blood flow blockage to the large intestine.
  • Mild cases are frequently underdiagnosed, leading to an underestimation of its true incidence.
  • Symptoms include abdominal pain, tenderness, and bloody diarrhea, with severe cases progressing to bowel necrosis and shock.

Purpose of the Study:

  • To provide an updated review of ischemic colitis, covering its presentation, diagnosis, and treatment.
  • To consolidate contemporary data from medical literature for clinical benefit.

Main Methods:

  • Literature review of current medical publications on ischemic colitis.
  • Extraction and synthesis of contemporary data regarding presentation, diagnosis, and treatment.

Main Results:

  • Ischemic colitis presents a spectrum of injury, commonly in the elderly, with symptoms like abdominal pain and bloody diarrhea.
  • Colonoscopy is the gold standard for diagnosis, while supportive care (fluids, bowel rest, antibiotics) leads to improvement in most patients within 1-2 days.
  • While conservative treatment resolves most cases, delayed diagnosis or severe ischemia carries risks of complications, death, and potential surgical intervention.

Conclusions:

  • Ischemic colitis requires prompt recognition and management.
  • Conservative treatment is effective for most patients, but vigilance for severe cases necessitating surgical intervention is crucial.
  • This review offers updated insights into the contemporary understanding and management of ischemic colitis.