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Updated: Jun 22, 2026
Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
Published on: September 8, 2021
Response analysis of non-hodgkin lymphoma using magnetic resonance imaging-based volumes
Maija Rossi1, Prasun Dastidar, Hannu Pertovaara
1Regional Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi
Objective:
The aim of this study was to determine the volume of non-Hodgkin lymphomas (NHLs) using semiautomatic segmentation and to correlate these results with clinical findings, treatment, and prognosis in patients with B-cell-type NHL.
Methods:
For this study, 29 patients with NHL underwent magnetic resonance imaging at 5 time points after onset of disease. Volumetric analysis of the tumors was accomplished with semiautomatic segmentation by the Anatomatic software.
Results:
The median tumor volumes from the first to the fifth examination were 468, 256, 90, 38, and 33 cm. Good correlation with 1-dimensional and 2-dimensional measures, used as standard methods in response categorization, was found. Surprisingly, volume reductions in excess of 239 cm after only 1 week of chemotherapy decreased the survival probability.
Conclusions:
Volume measurements seem to be highly informative for prognosis in the very early stages of treatment for patients with NHL.
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