Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regional mapping of CSF1R-positive microglia in neurodegenerative diseases and progressive MS, with exploratory presynaptic marker analyses.

Journal of neuroinflammation·2026

Same author

Features predicting data exclusion in imaging studies of Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same author

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025).

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer's disease.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Mapping brain beta-amyloid.

William Jagust¹

¹School of Public Health, University of California, Berkeley, CA 94720-3190, USA. jagust@berkeley.edu

Current Opinion in Neurology

|May 30, 2009

Summary

Amyloid PET imaging quantifies beta-amyloid in Alzheimer's disease research. While correlations with dementia exist, clinical utility for diagnosis and prediction depends on effective treatments and understanding downstream effects.

Area of Science:

Neuroimaging
Molecular Biology
Neurology

Background:

Alzheimer's disease (AD) pathogenesis is linked to beta-amyloid accumulation.
Positron Emission Tomography (PET) enables in vivo imaging of brain pathologies.

Purpose of the Study:

Review recent advancements in amyloid PET imaging.
Assess the quantification of brain beta-amyloid burden and distribution.
Discuss the role of beta-amyloid in AD pathogenesis.

Main Methods:

Review of current literature on amyloid PET imaging.
Analysis of in vivo versus histological measures of beta-amyloid deposition.
Correlation studies between beta-amyloid load and dementia indicators.

Main Results:

More Related Videos

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

Related Experiment Videos

Last Updated: Jun 22, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

Amyloid PET shows good agreement with histological beta-amyloid measures.
Beta-amyloid correlates with dementia severity, brain atrophy, and glucose metabolism.
Associations between beta-amyloid PET and cognition are generally weak.
Clinical utility for differentiating dementias and predicting AD is uncertain.

Conclusions:

Quantifying beta-amyloid progression aids research into AD vulnerability and the amyloid hypothesis.
Amyloid imaging has potential clinical implications for diagnosis and treatment monitoring.
Further research is needed to clarify the clinical utility of amyloid PET.