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Published on: August 15, 2019
Evaluating the utility of personal genomic information
Morris W Foster1, John J Mulvihill, Richard R Sharp
1Department of Anthropology, University of Oklahoma, Norman, Oklahoma 73019, USA. morris.w.foster-1@ou.edu
Summary
The utility of human genome-wide assays varies based on application. A broader definition encompassing personal utility, behavioral changes, and health awareness is crucial for comprehensive evaluation beyond clinical outcomes.
Area of Science:
- Genomics
- Bioethics
- Health Services Research
Background:
- Evaluating human genome-wide assays requires context-specific definitions of utility.
- Current assessments often use a restrictive clinical utility definition, potentially overlooking broader benefits.
Purpose of the Study:
- To explore diverse metrics for assessing the utility of human genome-wide assays.
- To advocate for a more expansive definition of utility that includes personal and societal benefits.
Main Methods:
- Conceptual analysis of clinical utility versus personal utility.
- Examination of cost-effectiveness in individual and societal contexts.
- Identification of metrics beyond traditional clinical outcomes.
Main Results:
- Clinical utility can exist without direct patient outcome changes and varies interindividually.
- Cost-effectiveness evaluations differ between individual and societal perspectives.
- Personal utility metrics include behavioral changes and increased health awareness.
Conclusions:
- A broader measure of overall utility, incorporating personal benefits, is necessary for human genome-wide assays.
- Interindividual variations in utility highlight the need for personalized assessment of genomic information benefits and risks.
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