Related Experiment Video

Updated: Jun 22, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Managing toxicities and optimal dosing of targeted drugs in advanced kidney cancer

B Seruga, H K Gan, J J Knox

    Current Oncology (Toronto, Ont.)
    |May 30, 2009
    PubMed

    Insights

    Early recognition and management of toxicities from new targeted drugs are crucial for maintaining treatment effectiveness in advanced kidney cancer. Fortunately, most drug-related toxicities can be managed with supportive care, avoiding treatment cessation.

    Area of Science:

    • Oncology
    • Pharmacology
    • Nephrology

    Background:

    • New targeted therapies offer promise for advanced kidney cancer.
    • Drug-induced toxicities can compromise treatment efficacy if not managed.
    • Early identification of adverse events is critical for patient outcomes.

    Purpose of the Study:

    • To highlight the importance of recognizing and managing toxicities associated with targeted drugs in advanced kidney cancer.
    • To emphasize that most toxicities are manageable, allowing treatment continuation.

    Main Methods:

    • Review of clinical data and literature on targeted therapies for advanced kidney cancer.
    • Analysis of common toxicities and their management strategies.
    • Assessment of the impact of supportive care on treatment adherence.

    Main Results:

    • Toxicities from targeted drugs can reduce treatment effectiveness in advanced kidney cancer.
    • Proactive management with supportive care is effective in mitigating most adverse events.
    • Treatment interruptions, dose reductions, or discontinuations are often unnecessary.

    Conclusions:

    • Effective management of drug toxicities is essential for optimizing targeted therapy outcomes in advanced kidney cancer.
    • Supportive care strategies enable sustained treatment, improving patient prognosis.
    • Early intervention for toxicities preserves treatment benefits and patient quality of life.
    Keywords:
    Sunitinibmanagementside effectssorafenibtemsirolimustoxicity

    More Related Videos

    Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

    Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

    Published on: April 12, 2021

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Related Concept Videos

    Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

    Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

    In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
    Renal Failure: Dose Adjustments01:11

    Renal Failure: Dose Adjustments

    In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
    Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
    However, dosage adjustments...
    Chronic Kidney Disease IV: Nursing Management01:18

    Chronic Kidney Disease IV: Nursing Management

    Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    Chronic Kidney Disease III: Interprofessional Care01:28

    Chronic Kidney Disease III: Interprofessional Care

    Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
    Kidney Transplant III: Nursing Management01:16

    Kidney Transplant III: Nursing Management

    Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...