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20 years' experience with ketoprofen.

E M Veys1

  • 1Kliniek voor Fysiotherapie en Orthopedie, Afdeling Reumatologie, Gent, Belgium.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1991
PubMed
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Ketoprofen is a potent nonsteroidal anti-inflammatory drug (NSAID) effective for arthritis and pain relief. Its varied formulations and favorable pharmacokinetic profile offer therapeutic joint concentrations with manageable side effects.

Area of Science:

  • Pharmacology
  • Rheumatology
  • Clinical Medicine

Background:

  • Ketoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) with established efficacy in treating inflammatory conditions like rheumatoid arthritis and osteoarthritis.
  • It also possesses significant analgesic properties, comparable to other NSAIDs in clinical use.

Purpose of the Study:

  • To review the clinical efficacy, pharmacokinetics, safety profile, and formulation diversity of ketoprofen.
  • To highlight ketoprofen's therapeutic advantages, including its effectiveness in joint conditions and varied administration routes.

Main Methods:

  • Review of clinical data and pharmacokinetic studies on ketoprofen.
  • Comparative analysis with other anti-inflammatory and analgesic agents.
  • Examination of available ketoprofen formulations and their clinical applications.

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Main Results:

  • Ketoprofen demonstrates comparable efficacy to other NSAIDs for inflammatory and analgesic purposes.
  • Its short plasma half-life does not necessitate dosage adjustments in the elderly, barring renal issues.
  • Delayed elimination from synovial fluid allows for sustained therapeutic joint concentrations.

Conclusions:

  • Ketoprofen is an effective NSAID with a favorable pharmacokinetic profile, suitable for various clinical scenarios.
  • Common side effects include gastrointestinal disturbances, similar to other NSAIDs.
  • Further research is needed to explore potential disease-modifying effects of ketoprofen and other NSAIDs.