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Antisecretory factor-inducing therapy improves the clinical outcome in patients with Ménière's disease

Per Hanner1, Helge Rask-Andersen, Stefan Lange

  • 1Department of Audiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Acta Oto-Laryngologica
|May 30, 2009
PubMed
Abstract

Insights

SPC-flakes significantly reduced vertigo in Ménière's disease (MD) patients. This treatment may improve vertigo by regulating fluid and ion transport in the inner ear.

Area of Science:

  • Otolaryngology
  • Neurology
  • Gastroenterology

Background:

  • Ménière's disease (MD) is a disorder of the inner ear.
  • Vertigo is a primary symptom of MD.
  • Current treatments for MD have limitations.

Purpose of the Study:

  • To evaluate the efficacy of SPC-flakes in reducing vertigo in MD patients.
  • To assess the safety and tolerability of SPC-flakes.
  • To explore potential mechanisms of action.

Main Methods:

  • Prospective, double-blind, placebo-controlled study.
  • 51 adult patients with MD were randomized to receive SPC-flakes or control cereals for 3 months.
  • Oto-neurological examinations were performed before and after treatment.

Main Results:

  • 14/27 patients receiving SPC-flakes reported decreased vertigo, versus 2/24 in the control group (p < 0.001).
  • No significant changes were observed in oto-neurological examinations.
  • SPC-flakes were well-tolerated.

Conclusions:

  • Intake of antisecretory factor (AF)-inducing SPC-flakes significantly reduced vertigo in Ménière's disease patients.
  • The therapeutic effect may involve modulation of water and ion transport in the endolymphatic space.
  • SPC-flakes represent a promising new treatment option for Ménière's disease.

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