Imaging tumour-bearing animals using clinical scanners

Area of Science:

• Oncology
• Medical Imaging
• Animal Research

Background:

• Clinical scanners offer advanced imaging capabilities.
• Small animal models are vital for cancer research.
• Integrating small animal imaging into clinical settings requires careful evaluation.

Purpose of the Study:

• To assess the utility of clinical imaging scanners (PET/CT, MRI) for small animal cancer research.
• To compare the capabilities of clinical scanners with dedicated small animal imaging systems.
• To identify challenges and best practices for small animal imaging in clinical environments.

Main Methods:

• Literature review of imaging principles, benefits, and drawbacks.
• Analysis of own experiences with small animal imaging in clinical scanners.
• Discussion of animal welfare considerations and their impact on imaging outcomes.

Main Results:

• Magnetic Resonance Imaging (MRI) in clinical scanners is effective for morphological and functional imaging of tumors in rodents.
• Positron Emission Tomography/Computed Tomography (PET/CT) in clinical settings shows feasibility for tumor imaging in mice, though resolution and sensitivity are limitations.
• Factors such as anesthesia, handling, and substance administration can affect animal physiology and subsequent imaging results.

Conclusions:

• Clinical scanners present a viable alternative to dedicated systems for various small animal cancer research applications, offering good image quality.
• Effective small animal imaging necessitates comprehensive knowledge of animal physiology and morphology.
• Understanding the influence of manipulation on imaging and prioritizing animal welfare are essential for obtaining meaningful results.