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Updated: Jun 22, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Is there a specific mutation of p53 gene due to radon exposure? A systematic review
Alberto Ruano-Ravina1, Maria J Faraldo-Valles, Juan M Barros-Dios
1Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain. alberto.ruano@usc.es
Purpose:
To review the existing literature analysing the influence of radon exposure on mutations in tumour protein 53 gene (TP53) in lung cancer patients.
Material And Methods:
Medline and EMBASE databases along with the International Agency for Research on Cancer (IARC) monographies were revised. Studies that had radon concentration as exposure variable and TP53 mutations as a result variable were included.
Results:
Eight studies were obtained, with a total of 578 individuals. They had been carried out on miners and on general population. A 26% of the miners' tumours had a mutation in gene TP53, versus a 24% in the population exposed to residential radon. A predominance of the AGG(ARG)--> ATG(MET) (Arginine to Methionine) mutation in miners was observed.
Conclusions:
The available results are not consistent in order to support the existence of a radon hotspot in TP53 gene. Future research should focus at least on exons 5 to 8, where most of the mutation clusters in lung tumours are observed.
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