Identifying risk factors for racial disparities in diabetes outcomes: the translating research into action for diabetes study
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O Kenrik Duru1, Robert B Gerzoff, Joseph V Selby
1Division of General Internal Medicine/Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. kduru@mednet.ucla.edu
Insights
Black patients with diabetes experience worse outcomes due to higher rates of depression and missed medication doses. Addressing these factors may reduce racial disparities in diabetes care.
Area of Science:
- Medical research
- Health disparities
- Diabetes management
Background:
- Black individuals with diabetes exhibit poorer glycemic control (hemoglobin A1c), elevated blood pressure (SBP), and higher LDL cholesterol compared to white individuals.
- These disparities are linked to increased morbidity and microvascular complications in Black patients.
Purpose of the Study:
- To investigate if mutable risk factors are more strongly associated with poor control of multiple diabetes outcomes in Black patients compared to White patients.
- To identify specific modifiable factors contributing to racial disparities in diabetes management.
Main Methods:
- A case-control study involving 764 Black and White patients with diabetes receiving care within managed health plans.
- Cases had poor control of at least two of three outcomes (HbA1c, SBP, LDL cholesterol); controls had good control of all three.
- Multivariate analyses assessed the association of depression, medication adherence, self-efficacy, and patient-provider communication with case/control status.
Main Results:
- Depression and missed medication doses were significantly associated with poor diabetes control (being a case) in Black patients (OR 2.28 and 1.96, respectively).
- These associations were not observed in White patients.
- Other assessed risk factors did not show significant associations for either racial group.
Conclusions:
- Depression and medication non-adherence are more strongly linked to poor diabetes control in Black individuals compared to White individuals.
- These findings highlight depression and medication adherence as critical targets for interventions aimed at reducing racial disparities in diabetes outcomes.
Background:
Versus whites, blacks with diabetes have poorer control of hemoglobin A1c (HbA1c), higher systolic blood pressure (SBP), and higher low-density lipoprotein (LDL) cholesterol as well as higher rates of morbidity and microvascular complications.
Objective:
To examine whether several mutable risk factors were more strongly associated with poor control of multiple intermediate outcomes among blacks with diabetes than among similar whites.
Design:
Case-control study.
Subjects:
A total of 764 blacks and whites with diabetes receiving care within 8 managed care health plans.
Measures:
Cases were patients with poor control of at least 2 of 3 intermediate outcomes (HbA1c > or =8.0%, SBP > or =140 mmHg, LDL cholesterol > or =130 mg/dL) and controls were patients with good control of all 3 (HbA1c <8.0%, SBP <140 mmHg, LDL cholesterol <130 mg/dL). In multivariate analyses, we determined whether each of several potentially mutable risk factors, including depression, poor adherence to medications, low self-efficacy for reducing cardiovascular risk, and poor patient-provider communication, predicted case or control status.
Results:
Among blacks but not whites, in multivariate analyses depression (odds ratio: 2.28; 95% confidence interval: 1.09-4.75) and having missed medication doses (odds ratio: 1.96; 95% confidence interval: 1.01-3.81) were associated with greater odds of being a case rather than a control. None of the other risk factors were associated for either blacks or whites.
Conclusions:
Depression and missing medication doses are more strongly associated with poor diabetes control among blacks than in whites. These 2 risk factors may represent important targets for patient-level interventions to address racial disparities in diabetes outcomes.
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