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Updated: Jun 22, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Autoimmune thyroid disease--a continuous spectrum
Raluca Trifănescu1, Cătălina Poiană, D Hortopan
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. ralucatrifanescu@yahoo.com
Aim:
to present a case report revealing a variant of natural history of autoimmune thyroid disease.
Case Report:
I.F., a 39 years old woman, had a previous medical history of Graves' disease treated with antithyroid drugs (ATD). After 1 year of treatment, the remission was confirmed one and two years after ATD withdrawal. Twenty years after the initial hyperthyroidism, spontaneous subclinical hypothyroidism was diagnosed. The patient presented both anti TSH-receptor (TSH-R) antibodies (Ab), antithyroperoxidase (TPO) and antithyroglobulin (antiTgl) antibodies in elevated titres.
Conclusion:
Because of the shift from hyperthyroidism to euthyroidism or to spontaneous hypothyroidism, Graves' disease patients demand a strict follow-up after ATD therapy. It seems that there is an effect of TPOAb on thyroid destruction.
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