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Updated: Jun 22, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
An unusual presentation of gastrointestinal obstruction in a three-year-old boy
Ozlem Boybeyi1, Arbay Ozden Ciftçi, Haluk Topaloğlu
1Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Insights
This study details a rare case of severe intestinal obstruction linked to enteric nervous system issues, megacystis, and urination problems. Pyridostigmine treatment proved highly effective for the patient.
Area of Science:
- Gastroenterology and Urology
- Neurogastroenterology
- Pediatric Medicine
Background:
- Intestinal obstruction is a common surgical emergency.
- Enteric nervous system (ENS) abnormalities can lead to various gastrointestinal dysmotilities.
- Megacystis and micturition difficulties suggest potential autonomic dysfunction.
Observation:
- A patient presented with severe, intermittent intestinal obstruction.
- The obstruction was suspected to be related to an underlying enteric nervous system abnormality.
- Concurrent symptoms included megacystis and micturition difficulty, pointing towards a broader neuro-urological involvement.
Findings:
- The patient's condition was most likely caused by an enteric nervous system abnormality.
- Pyridostigmine, a medical treatment, demonstrated significant success in managing the intestinal obstruction.
- Clinicopathologic features of this rare condition were analyzed.
Implications:
- This case highlights a potential link between ENS dysfunction, megacystis, and intestinal obstruction.
- Pyridostigmine may be a viable therapeutic option for similar rare presentations.
- Further research into the etiopathogenesis of this entity is warranted to improve diagnostic and treatment strategies.
Abstract:
We report a case presenting with severe intermittent intestinal obstruction, most probably due to enteric nervous system abnormality associated with megacystis and micturition difficulty. Medical treatment consisting of pyridostigmine was very successful in our patient. The clinicopathologic features of this very rare entity and its medical treatment are discussed with a brief review of the etiopathogenesis.
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