[Association between adiposity measures, demographic and biochemical variables with C-reactive protein serum levels...

Association between adiposity measures, demographic and biochemical variables with C-reactive protein serum levels in rural population. Acute-phase proteins as C-reactive protein (CRP) have been associated with cardiovascular diseases. Recent studies have shown the relation between body fat and elevated serum levels of CRP. This study verifies relation between adiposity measures, demographic and biochemical variables with CRP serum levels in a rural population. The study was conducted among individuals aged 18 or more, both sexes and at least two years of residency in the place of study. Pregnant women, diabetic and CRP over 10 mg/l individuals were excluded. Data collection included anthropometric, demographic, lifestyle and biochemical variables. Data was processed in STATA 9.0. From the 536 subjects, 50.37% were men. Age varied from 18 to 94, age mean was 43.34. Overweight and obesity prevalence were significantly higher among women than men. Bivariate analysis found significant correlations between lnCRP and the following variables: BMI, waist circumference, WHR, age, education, systolic and diastolic blood pressure, total cholesterol, LDL-c, HDL-c, triglycerides, fasting insulin and HOMA-IR. After adjusting for confounding variables in multiple linear regression analysis only BMI, age, sex, fasting insulin and HDL-c remained significantly associated with lnCRP. The independent association of traditional risk factors for cardiovascular disease (age, sex, BMI, fasting insulin and HDL-c) with PCR evidences a close relationship between adipose tissue, cardiovascular diseases and inflammation.