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Related Concept Videos

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Prokaryotic Cells01:51

Prokaryotic Cells

Prokaryotes are small unicellular organisms that include the domains—Archaea and Bacteria. Bacteria include many common organisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins. However,...

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Related Experiment Video

Updated: Jun 22, 2026

Self-reporting Scaffolds for 3-Dimensional Cell Culture
14:49

Self-reporting Scaffolds for 3-Dimensional Cell Culture

Published on: November 7, 2013

Self-reporting cells.

Corey Nislow1

  • 1Department of Molecular Genetics, University of Toronto, Donnelley CCBR, 160 College St., Rm. 1210, Toronto, ON M5S 3E1, Canada. corey.nislow@gmail.com

Biotechniques
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Designer cells, engineered using advances in synthetic biology and genomics, will soon report on cell physiology. This technology opens new biological inquiry avenues and enhances understanding of cell function.

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Area of Science:

  • Biotechnology
  • Synthetic Biology
  • Genomics

Background:

  • Biomarker discovery, synthetic biology, and next-generation genomics are rapidly advancing.
  • These fields hold the potential to engineer cells with novel functionalities.

Purpose of the Study:

  • To explore the potential of engineered "designer cells" in biological research.
  • To highlight how these cells can report on physiological states.

Main Methods:

  • Leveraging advances in biomarker discovery.
  • Utilizing synthetic biology tools for cell engineering.
  • Applying next-generation genomics for cellular analysis.

Main Results:

  • Engineered cells can be designed to report on diverse physiological aspects.
  • This capability promises to provide new biological insights.

Conclusions:

  • Designer cells are nearing reality due to technological progress.
  • These engineered cells offer enhanced understanding of cell function and open new research avenues.