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[Evaluation of cardiovascular risk in the cross-sectional phase of the Mediterranean Study]
V Gil-Guillén1, J Merino-Sánchez, T Sánchez-Ruiz
1REDIAPP-CV. Unidad de Investigación. Docencia y Práctica Clínica. Universidad Miguel Hernández, Elche, Alicante, España. info@sicccro.com
Insights
The SCORE scale identifies more high cardiovascular risk (HCR) patients than the REGICOR scale in hypertensive individuals, though consistency between the two risk assessment tools is poor. Significant altered blood pressure and high total cholesterol were observed.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Context:
- Cardiovascular risk assessment is crucial for preventing heart disease.
- Existing risk scales like REGICOR and SCORE have varying performance.
- Hypertension and hypercholesterolemia are significant cardiovascular risk factors.
Purpose:
- To quantify high cardiovascular risk (HCR) using REGICOR and SCORE scales.
- To assess the consistency between REGICOR and SCORE in hypertensive and hypercholesterolemic patients.
- To analyze altered blood pressure (ABP), high total cholesterol (HTC), and cardiac/renal damage in these patient groups.
Summary:
- The SCORE scale identified more patients with HCR than the REGICOR scale in hypertensive patients (26.1% vs 17.3%) and a similar proportion in hypercholesterolemic patients (21.5% vs 21.1%).
- Consistency between the REGICOR and SCORE scales was poor (ICC = 0.222 for HT, ICC = 0.190 for HC).
- Significant prevalence of HTC (64.7%) and ABP (33.7%) was found, along with notable rates of cardiac and renal damage in hypertensive patients.
Impact:
- Highlights the discrepancies in cardiovascular risk stratification between commonly used scales.
- Underscores the high prevalence of uncontrolled risk factors and end-organ damage in hypertensive and hypercholesterolemic populations.
- Informs clinical practice regarding the selection and application of cardiovascular risk assessment tools.
Introduction And Objectives:
The Mediterranean study quantifies high cardiovascular risk (HCR), consistency between REGICOR (R) and low risk SCORE (LS) scales, altered blood pressure (ABP) values in hypercholesterolemia (HC) without any history of hypertension (HT), high total cholesterol (HTC) values with HT with no background of HC and cardiac and renal damage in hypertensive patients.
Patients And Methods:
A national, cross-sectional and multicenter study was performed with the participation of 751 physicians. The physicians individually evaluated 7,973 patients with HT and 5,319 with HC. HCR was defined as over 10% with R and 5% with LS. Intra-class correlation coefficient (ICC) and Pearson coefficient (r) were calculated. The percentages of ABP and HTC were quantified. Creatinine (cr) value, glomerular filtration rate using Cockroft-Gault (CG), and prevalence of left ventricular hypertrophy (LVH) were analyzed.
Results:
Regarding hypertensive patients: 17.3% HCR with R and 26.1% with LS. ICC = 0.222 (p < 0.0001), r = 0.61 (p < 0.0001), 64.7% HTC. There was no evaluation of LVH in 31.2% and a prevalence of 5.1%, prevalence of lesion and kidney failure (KF) of 4.7% and 1.6% respectively based on CR and 15.9% KF by CG. In HC patients, there was 21.1% of HCR with R and 21.5% with LS; ICC = 0.190 (p < 0.0001), r = 0.64 (p < 0.0001) and 33.7% ABP.
Conclusions:
The SCORE scale identifies more patients with HCR than the REGICOR one in HT patients and a similar amount in HC patients. Consistency between both scales is poor. A significant ABP/HTC was found. In HT patients, the patients who were not evaluated for LVH and the percentage of KF are important.
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