Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection
Mikko Seppänen1, Marja-Liisa Lokki, Maija Lappalainen
1Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.
Human Immunology
|June 2, 2009
Summary
Mannose-binding lectin (MBL) deficiency, linked to MBL2 variant genotypes, increases the risk of recurrent herpes simplex virus 2 (HSV-2) infections. This suggests MBL plays a role in controlling HSV-2 recurrence.
Area of Science:
- Immunology
- Genetics
- Virology
Background:
- Mannose-binding lectin (MBL) is a key component of the innate immune system.
- MBL acts as an opsonic factor, facilitating the recognition and clearance of pathogens, including herpes simplex virus 2 (HSV-2).
- Genetic variations in the MBL2 gene can lead to altered MBL levels and function.
Purpose of the Study:
- To investigate the association between MBL2 genotypes and the risk of recurrent herpes simplex virus 2 (HSV-2) infection.
- To determine if specific MBL2 structural variant genotypes predispose individuals to recurring HSV-2 infections.
Main Methods:
- Case-control study comparing MBL2 genotypes in patients with recurrent HSV-2 infection and control groups.
- Genotyping of MBL2 structural variants (A/O or O/O).
- Statistical analysis including odds ratios (OR) and confidence intervals (CI) to assess risk.
Main Results:
- MBL2 structural variant genotypes (A/O or O/O) were significantly more prevalent in patients with recurrent HSV-2 infection compared to healthy controls (47% vs 26%).
- The odds of recurrent HSV-2 infection were higher for individuals with MBL2 structural variant genotypes compared to both healthy controls (OR = 2.6) and HSV-2 antibody-positive controls (OR = 4.9).
- A statistically significant association was found between MBL2 structural variant genotypes and recurrent HSV-2 infection (p = 0.005 and p = 0.007).
Conclusions:
- MBL2 structural variant genotypes are associated with an increased risk of developing recurrent HSV-2 infection.
- Impaired recognition of HSV-2 due to MBL deficiency may contribute to the predisposition to recurring infections.
- MBL genotype could be a potential factor influencing the clinical course of HSV-2 infections.
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