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Related Experiment Video

Updated: Jun 22, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

Nerve growth factor in rheumatic diseases.

Matthias F Seidel¹, Marjeta Herguijuela, Randolf Forkert

¹Medizinische Klinik und Poliklink I, Rheumatology, Bonn, Germany. Matthias.Seidel@ukb.uni-bonn.de

Seminars in Arthritis and Rheumatism

|June 2, 2009

Summary

Nerve growth factor (NGF) plays a key role in rheumatic diseases, acting as a mediator of inflammation. Targeting NGF may offer new therapeutic strategies for conditions like rheumatoid arthritis.

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Last Updated: Jun 22, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

Area of Science:

Neuroimmunology
Rheumatology
Molecular Biology

Background:

The nervous system influences immune responses in autoimmune conditions via neurogenic inflammation.
Nerve growth factor (NGF) is crucial for neuronal survival and growth, and also modulates immune responses.
Evidence suggests NGF is a significant mediator in various immune and rheumatic diseases.

Purpose of the Study:

To review the role of nerve growth factor (NGF) in rheumatic diseases.
To explore potential therapeutic interventions targeting NGF in these conditions.

Main Methods:

Conducted a comprehensive database search (Medline, Medpilot) for articles on NGF and rheumatic conditions.
Included clinical trials, human specimen studies, and relevant animal model studies.
Analyzed 800 abstracts for relevance and content.

Main Results:

Nerve growth factor (NGF) is overexpressed in numerous inflammatory and degenerative rheumatic diseases.
NGF concentrations correlate with disease activity and inflammation extent in many conditions.
Significantly higher NGF levels were observed in rheumatoid arthritis compared to osteoarthritis.

Conclusions:

Nerve growth factor (NGF) is a critical mediator and modulator of inflammation in rheumatic diseases.
NGF exhibits both detrimental and regenerative effects, suggesting complex roles.
Therapeutic strategies involving NGF antagonists or recombinant NGF show potential.